[HTML][HTML] Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit
MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as
well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic
lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked
mutations in MED12 disrupt its ability to activate cyclin C (CycC)–dependent kinase 8
(CDK8) in Mediator, implicating impaired Mediator-associated CDK8 activity in the …
MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as
well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic
lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked
mutations in MED12 disrupt its ability to activate cyclin C (CycC)–dependent kinase 8
(CDK8) in Mediator, implicating impaired Mediator-associated CDK8 activity in the …
