Evolving therapeutic goals in ulcerative colitis: towards disease clearance

S Danese, G Roda, L Peyrin-Biroulet - … Reviews Gastroenterology & …, 2020 - nature.com
S Danese, G Roda, L Peyrin-Biroulet
Nature Reviews Gastroenterology & Hepatology, 2020nature.com
In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse
and hospitalization, pushing for histological remission to be embraced in clinical practice
and clinical trials. Here, we propose the concept of disease clearance (symptomatic,
endoscopic and histological remission) as the ultimate goal in the treatment of ulcerative
colitis.
In ulcerative colitis, treating beyond endoscopic healing has shown a reduction of relapse and hospitalization, pushing for histological remission to be embraced in clinical practice and clinical trials. Here, we propose the concept of disease clearance (symptomatic, endoscopic and histological remission) as the ultimate goal in the treatment of ulcerative colitis.
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